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Agrochemical CMO service <General Name > intermediates to active ingredients
Service overview
AGC Chemicals offer contract manufacturing for everything from agrochemical intermediates to active ingredients(AI) matched to customers’ needs using precision organic synthesis technology. With our efficient development process, we supply inexpensive intermediates and ingredients on an industrial scale. AGC Chemicals is dispersing risk and producing a stable supply of products by having production plants in various parts of Japan.
Features
- Stable production based on risk dispersal -
AGC Chemicals is dispersing risk and creating a stable supply of products by having production plants in various parts of Japan.
- One-stop solution including everything from development to manufacturing -
Using fine organic synthesis technology, AGC Chemicals is able to integrate our production from intermediates to ingredients.
We are able to conduct contract manufacturing of low price intermediates and ingredients on an industrial scale based on efficient process development through the provision of a one stop solution process from development to manufacturing.
- Systematic management systems and high quality -
AGC Chemicals offer high quality, stable production based on systematic management systems.
In response to requests, we also comply with cGMP plant manufacturing and FDA inspections.
Manufacturing bases / equipment
＜AGC Chiba Plant＞ (Ichihara City, Chiba Prefecture) *cGMP compliant equipment
| Material | Volume | Design Temp. (°C) | Number | |
|---|---|---|---|---|
| Reactors | Glass Lining | 1,000 ~ 6,000L | -30 ~ 180°C | 2 |
| Hastelloy C | 100 ~ 1,000L | -100 ~ 180°C | 2 | |
| SUS | 1,000 ~ 3,000L | -100 ~ 400°C | 7 | |
| Fluororesin Lining | 200L | - | 1 | |
| Multi-tubular reactor | Inconel | - | ||
| Distillation Towers | SUS | 230 ~ 2,400L | - | - |
| Centrifugal separator | various | φ42B | - | - |
| Pressure filters | SUS | 500 ~ 1,500φ | - | - |
| Dryers | various | 1,000 ~ 1,200L | - | |
| Filter dryer | SUS | 2,000L | - | - |
| Refrigerators | various | - | - | |
| Thin film evaporator | SUS | - | - |
Environment management level: The plant has manufacturing rooms with 100,000 particles / ft3
We are equipped with chemical reactors and peripheral equipment appropriate for fluorination.
< AGC Wakasa Chemicals: Obama Plant / pharmaceuticals Plant > (Obama City, Fukui Prefecture)
- cGMP compliant
- Starting materials and raw materials
| Equipment | Material | Volume (L) | Numbers | Design Temp. (°C) |
|---|---|---|---|---|
| Reactors | SUS, Glass Lining, Hastelloy C, Resin | 100 to 5,000 | 45 | -50 to 210 |
| Distillation Towers | SUS, Glass Lining | up to 2,000 | 2 | - |
| Centrifugal separators | SUS, Resin | up to 48inch | 8 | - |
| Mixed dryer | SUS, Glass Lining | 300 to 2,000 | 4 | - |
| Filter dryer | SUS | 300 to 1,700 | 4 | - |
We are capable of synthesizing from 1 kg to 100 t centered on pharmaceutical / agrochemical intermediates
We have equipment capable of manufacturing pharmaceutical ingredients.
< AGC Wakasa Chemicals: Kaminaka Plant > (Wakasa-cho, Mikata Kaminaka-gun, Fukui Prefecture)
- Intermediates and active ingredients
- Agrochemical CDMO
| Equipment | Material | Volume (L) | Numbers | Design Temp. (°C) |
|---|---|---|---|---|
| Reactors | SUS, Glass Lining, Hastelloy C, Alloy | 200 to 14,000 | 49 | -45 to 250 |
| Distillation Towers | SUS, Glass Lining | up to 8,000 | 7 | - |
| Centrifugal separator | SUS, Resin | up to 48inch | 8 | - |
| Mixed dryer | SUS, Glass Lining | up to 4,000 | 7 | - |
We have equipment responsive to increased demand for agrochemical intermediates and ingredients.
< AGC Seimi Chemical > (Chigasaki City, Kanagawa Prefecture)
| Material | Volume | Design Temp. (°C) | Number | |
|---|---|---|---|---|
| Reactors | Glass Lining | 100 ~ 3,000L | - | 12 |
| SUS | 100 ~ 1,000L | -50 ~ 180°C | 7 | |
| Hastelloy C | 200 ~ 500L | -80 ~ 200°C | 4 | |
| Fluororesin Lining | 1,500L | -30 ~ 60°C | 1 | |
| Distillation Towers | Various | 300 ~ 1,000L | ||
| Centrifugal separators | Various | φ20 ~ 36inch | ||
| Pressure filters | Fluororesin Lining | ~ 900φ | ||
| Columns | SUS | ~ 300φ | ||
| Dryers | Various | 500～800L |
We carry out contract synthesis of functional chemicals and pharmaceutical intermediates.
Special technology
AGC Chemicals is a fluorine chemical manufacturer with extensive experience in fluorine chemistry and is equipped with world leading technological and production capabilities able to handle the 4 main halogens. We have a prolific track record in halogenation, including fluorination, and ultra low temperature reactions, and respond to the diverse needs of customers.
■ Halogenation
Halogen exchange reactions
Nucleophilic fluorination
Electrophilic fluorination
Diazo fluorination
“PERFECT” process
Electrolysis fluorination
Apart from the above, reactions using anhydrous fluoride (HF), fluorine gas (F2),tetrafluoroethylene (TFE), chlorotrifluoroethylene, (CTFE) and iodine pentafluoride (IF5), etc., are also possible.
■ Ultra low temperature reactions
Down to a minimum temperature of -100°°C
■ Use of fluorine-containing building blocks
Heterocyclic compounds
Fluoroalkyl group introduction
■ Various types of organic synthesis
Friedel-Crafts
Grignard
Various types of cross coupling
Oxidation
Reduction (hydrogenation)
High pressure reactions (toxic / combustible high pressure gas)
High temperature reactions
- Photoreactions (e.g.: using UV, etc.)
- Polypetides / oligomerization
- Polymer reactions
- Optically active compounds (enantioselective synthesis)
- Terminal functional group protection
- Distillation (atmospheric distillation, pressurized distillation, vacuum distillation, extraction distillation, water steam distillation)
- Granulation
- Pulverization
- High purity refining
- Use of ion-exchange resins / ion-exchange membranes
- High vacuum
- Use of membrane technology
- Gas phase thermal decomposition reaction
Environment measures
We have activated sludge waste water treatment equipment, HF-containing waste gas treatment equipment and organic fluorine compound incineration equipment.
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