Agrochemical CMO service <General Name > intermediates to active ingredients

Service overview

AGC Chemicals offer contract manufacturing for everything from agrochemical intermediates to active ingredients(AI) matched to customers’ needs using precision organic synthesis technology. With our efficient development process, we supply inexpensive intermediates and ingredients on an industrial scale. AGC Chemicals is dispersing risk and producing a stable supply of products by having production plants in various parts of Japan.


- Stable production based on risk dispersal -

AGC Chemicals is dispersing risk and creating a stable supply of products by having production plants in various parts of Japan.

- One-stop solution including everything from development to manufacturing -

Using fine organic synthesis technology, AGC Chemicals is able to integrate our production from intermediates to ingredients.
We are able to conduct contract manufacturing of low price intermediates and ingredients on an industrial scale based on efficient process development through the provision of a one stop solution process from development to manufacturing.

- Systematic management systems and high quality -

AGC Chemicals offer high quality, stable production based on systematic management systems.
In response to requests, we also comply with cGMP plant manufacturing and FDA inspections.

Manufacturing bases / equipment

<AGC Chiba Plant> (Ichihara City, Chiba Prefecture) *cGMP compliant equipment

MaterialVolumeDesign Temp. (°C)Number
ReactorsGlass Lining1,000 ~ 6,000L-30 ~ 180°C2
Hastelloy C100 ~ 1,000L-100 ~ 180°C2
SUS1,000 ~ 3,000L-100 ~ 400°C7
Fluororesin Lining200L-1
Multi-tubular reactorInconel-
Distillation TowersSUS230 ~ 2,400L--
Centrifugal separator variousφ42B--
Pressure filtersSUS500 ~ 1,500φ--
Dryersvarious1,000 ~ 1,200L-
Filter dryerSUS2,000L--
Thin film evaporator SUS--

Environment management level: The plant has manufacturing rooms with 100,000 particles / ft3

We are equipped with chemical reactors and peripheral equipment appropriate for fluorination.

< AGC Wakasa Chemicals: Obama Plant / pharmaceuticals Plant > (Obama City, Fukui Prefecture)

cGMP compliant
Starting materials and raw materials
EquipmentMaterialVolume (L)NumbersDesign Temp. (°C)
ReactorsSUS, Glass Lining,

Hastelloy C, Resin
100 to 5,00045-50 to 210
Distillation TowersSUS, Glass Liningup to 2,0002-
Centrifugal separatorsSUS, Resinup to 48inch8-
Mixed dryerSUS, Glass Lining300 to 2,0004-
Filter dryerSUS300 to 1,7004-

We are capable of synthesizing from 1 kg to 100 t centered on pharmaceutical / agrochemical intermediates

We have equipment capable of manufacturing pharmaceutical ingredients.

< AGC Wakasa Chemicals: Kaminaka Plant > (Wakasa-cho, Mikata Kaminaka-gun, Fukui Prefecture)

Intermediates and active ingredients
Agrochemical CDMO
EquipmentMaterialVolume (L)NumbersDesign Temp. (°C)
ReactorsSUS, Glass Lining,

Hastelloy C, Alloy
200 to 14,00049-45 to 250
Distillation TowersSUS, Glass Liningup to 8,0007-
Centrifugal separator SUS, Resinup to 48inch8-
Mixed dryerSUS, Glass Liningup to 4,0007-

We have equipment responsive to increased demand for agrochemical intermediates and ingredients.

< AGC Seimi Chemical > (Chigasaki City, Kanagawa Prefecture)

MaterialVolumeDesign Temp. (°C)Number
ReactorsGlass Lining100 ~ 3,000L-12
SUS100 ~ 1,000L-50 ~ 180°C7
Hastelloy C200 ~ 500L-80 ~ 200°C4
Fluororesin Lining1,500L-30 ~ 60°C1
Distillation TowersVarious300 ~ 1,000L
Centrifugal separatorsVariousφ20 ~ 36inch
Pressure filtersFluororesin Lining~ 900φ
ColumnsSUS~ 300φ

We carry out contract synthesis of functional chemicals and pharmaceutical intermediates.

Special technology

AGC Chemicals is a fluorine chemical manufacturer with extensive experience in fluorine chemistry and is equipped with world leading technological and production capabilities able to handle the 4 main halogens. We have a prolific track record in halogenation, including fluorination, and ultra low temperature reactions, and respond to the diverse needs of customers.

■ Halogenation

Halogen exchange reactions
Nucleophilic fluorination
Electrophilic fluorination
Diazo fluorination
“PERFECT” process
Electrolysis fluorination
Apart from the above, reactions using anhydrous fluoride (HF), fluorine gas (F2),tetrafluoroethylene (TFE), chlorotrifluoroethylene, (CTFE) and iodine pentafluoride (IF5), etc., are also possible.

■ Ultra low temperature reactions

Down to a minimum temperature of -100°°C

■ Use of fluorine-containing building blocks

Heterocyclic compounds
Fluoroalkyl group introduction

■ Various types of organic synthesis

Various types of cross coupling
Reduction (hydrogenation)
High pressure reactions (toxic / combustible high pressure gas)
High temperature reactions

Photoreactions (e.g.: using UV, etc.)
Polypetides / oligomerization
Polymer reactions
Optically active compounds (enantioselective synthesis)
Terminal functional group protection
Distillation (atmospheric distillation, pressurized distillation, vacuum distillation, extraction distillation, water steam distillation)
High purity refining
Use of ion-exchange resins / ion-exchange membranes
High vacuum
Use of membrane technology
Gas phase thermal decomposition reaction

Environment measures

We have activated sludge waste water treatment equipment, HF-containing waste gas treatment equipment and organic fluorine compound incineration equipment.