Fluorinated compounds <General Name > Custom synthesis

Service overview

AGC Chemicals is a fluorine chemical manufacturer with extensive experience in fluorine chemistry and is equipped with world leading technological and production capabilities able to handle the 4 main halogens.
We have a prolific track record in various types of organic synthesis, general fluorination, halogenation, ultra low temperature reactions, etc.

Using fluorination technology that is our speciality, we offer contract manufacturing of fluorinated compounds matched to our customers' needs from laboratory scale to industrial scale based on efficient process development.

AGC Chemicals contract manufacturing

Owned technology

■ Halogenation

Halogen exchange reactions
Nucleophilic fluorination
Electrophilic fluorination
Diazo fluorination
“PERFECT” process
Electrolysis fluorination
Apart from the above, reactions using anhydrous fluoride (HF), fluorine gas (F2),tetrafluoroethylene (TFE), chlorotrifluoroethylene, (CTFE) and iodine pentafluoride (IF5), etc., are also possible.

■ Ultra low temperature reactions

Down to a minimum temperature of -100°C

■ Use of fluorine-containing building blocks

Heterocyclic compounds
Fluoroalkyl group introduction

■ Various types of organic synthesis

Friedel-Crafts
Grignard
Various types of cross coupling
Oxidation
Reduction (hydrogenation)
High pressure reactions (toxic / combustible high pressure gas)
High temperature reactions

Photoreactions (e.g.: using UV, etc.)
Polypetides / oligomerization
Polymer reactions
Optically active compounds (enantioselective synthesis)
Terminal functional group protection
Distillation (atmospheric distillation, pressurized distillation, vacuum distillation, extraction distillation, water steam distillation)
Granulation
Pulverization
High purity refining
Use of ion-exchange resins / ion-exchange membranes
High vacuum
Use of membrane technology
Gas phase thermal decomposition reaction

Halogenation (fluorination, chlorination, bromination, iodination)

AGC Chemicals is able to handle the 4 main halogens based on our own company's fluorination technology.

Ultra low temperature reactions

AGC Chemicals has equipment capable of handling temperatures down to -100°C for ultra low temperature reactions that control side reactions.

AGC Inc. Chiba Plant:GL 3000L, HC 1000L
AGC Seimi Chemical Co., Ltd.: 500L x 2, 200L x 1

Here are some example reactions

3. Use of fluorine-containing building blocks

AGC Chemicals also handles the use of and supply fluorine-containing building blocks (molecules with fluorine atoms and terminal functional groups) using our company's tetrafluoroethylene (TFE), chlorotrifluoroethylene, (CTFE) and trifluoroacetic acid, too.

Examples of raw materials that can be used

No.CAS No.CHEMICAL NAME
176-05-1Trifluoroacetic acid
2407-25-0Trifluoroacetic anhydride
3383-63-1Ethyl trifluoroacetate
42923-18-4Sodium trifluoroacetate
5354-38-1Trifluoroacetamide
6677-69-0Heptafluoro-2-iodopropane
7455-14-14-(trifluoromethyl)aniline
8122665-97-84,4-difluorocyclohexane carboxylic acid
9148043-73-64,4,5,5,5-Pentafluoro-1-pentanol
1030071-93-33,5-Bis(trifluoromethyl)acetophenone
113862-73-52,3,4-Trifluoroaniline
12328-93-82,5-Bis(trifluoromethyl)aniline
13214557-89-83,5,7-trifluoroadamantane carboxylic acid
14118612-00-3N,N-Dimethylanilinium tetrakis-(pentafluorophenyl)borate
15136040-19-2Triphenylcarbenium tetrakis-(pentafluorophenyl) borate
1675-29-62-chloropropane
17557-98-22-chloropropene
1810061-02-6trans-1,3-dichloropropene
1910061-02-5cis-1,3-dichloropropene
2098-18-41,2,3-trichloropropane
21142-28-91,3-dichloropropane
2298-24-23-chloro-1,2-propanediol
2396-23-11,3-dichloro-2-propanol
24627-30-53-chloro-1-propanol
25616-30-83-amino-1,2-propanediol
26616-29-51,3-diamino-2-propanol
27107-11-93-amino-1-propene
2878-90-01,2-diaminopropane
29109-76-21,3-diaminopropane
3076-31-02-aminopropane
31870787-05-6methyl 3-(trifluoromethyl)pyrazine-2-carboxylate
32873056-62-33',4'-difluorobiphenyl-2-amine

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Inquiries

Sales contactTELFAXADDRESSWEB
JapanAGC Inc.+81-3-3218-5462+81-3-3218-7854Shin-Marunouchi Bidg., 1-5-1
Marunouchi Chiyoda-ku, Tokyo, Japan
http://www.agc.co.jp/
EUAGC CHEMICALS EUROPE , LTD+31-20-880-4170+31-20-880-4188Zuidplein 80 1077 VX
Amsterdam , The Netherlands
http://www.agcce.com/
USAAGC CHEMICALS AMERICAS , INC.+1-610-423-8119+1-610-423-430155 East Uwchlan Ave , Suite
201 Exton , PA 19341
http://www.agcchem.com/

Inquiries may be made by e-mail using the inquiries form on our company's website.